Sunday, March 31, 2013

Meryl Streep?s Daughter Mamie Gummer Divorcing

Meryl Streep’s Daughter Mamie Gummer Divorcing

Meryl Streep daughter Mamie GummerMamie Gummer, the daughter of actress Meryl Streep, is getting a divorce after less than two years of marriage. The “Emily Owens, MD” star, 29, and her husband, Broadway actor Benjamin Walker, 30, have decided to split. Mamie’s rep confirmed the split, adding, “It?s very amicable.” The couple met in 2008 while co-starring together in ...

Meryl Streep’s Daughter Mamie Gummer Divorcing Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/03/meryl-streeps-daughter-mamie-gummer-divorcing/

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Authorities: $600M scheme incubated in N.C. town

LEXINGTON, N.C. (AP) ? In the hardware store on South Main Street, the owner pulled Caron Myers aside to tell her about the best thing to happen in years to this once-thriving furniture and textile town.

Did she hear about the online company ZeekRewards? For a small investment, she could make a fortune. He had invested. So had his grandsons. And so were more and more people in Lexington, including doctors, lawyers and accountants.

Skeptical at first, Myers drove a few blocks to the company's one-story, red-brick office and spotted a line of people circling the building. She was sold, and plunked down several thousand dollars. But months later, Myers, like hundreds of thousands of others, discovered the truth: ZeekRewards was a scam.

"I was duped," Meyer said. "We trusted this man. The community is still in shock."

Authorities say owner Paul Burks was the mastermind of a $600 million Ponzi scheme ? one of the biggest in U.S. history ? that attracted 1 million investors, including nearly 50,000 in North Carolina. Many were recruited by friends and family in Lexington, a quintessential small town where neighbors look out for each other.

But what investors didn't know was that regulators had received nearly a dozen complaints about ZeekRewards and the related site Zeekler.com, but failed to take action for months, leaving the company free to recruit tens of thousands of new victims.

The Securities and Exchange Commission, which closed the operation Aug. 17, said Burks was selling securities without a license. The Ponzi scheme was using money from new investors to pay the earlier ones.

Burks has agreed to pay a $4 million penalty and cooperate with a federal court-appointed receiver trying to recover hundreds of millions of dollars.

Investigators say Burks, a former nursing home magician, siphoned millions for his personal use. But he has not been charged.

In his first public comments, Burks told The Associated Press he couldn't discuss details because of lawsuits by victims trying to recoup money.

"Everything will come out in time," said Burks, 66, standing in the doorway of his home.

Asked if he had anything to say to victims, he shook his head.

"I never told anyone to invest more money than they could afford," Burks snapped. "I didn't tell them to do that. Never."

He said if they lost money, "it's their fault. Not mine. Don't blame me."

But Cal Cunningham, a former prosecutor representing investors in a lawsuit, slammed Burks ? and regulators for taking so long to act.

"It's why we need a full hearing on what happened in a court of law ? whether that be our civil case or a criminal proceeding. A lot of people were hurt," he said.

____

Burks started Zeekler in early 2010 as an online penny auction site. His business experience included nearly four decades in multilevel marketing programs ? such as Amway ? including failed attempts to launch similar businesses of his own.

In penny auctions, consumers compete to pay pennies on the dollar for name brand products such as iPads. Each bid costs as much as $1, so participating can become expensive and the sites can earn nice profits when multiple users bid against each other.

In January 2011, he incorporated aspects of multilevel marketing into the business when he launched ZeekRewards. The program offered a share of the penny auction's profits to people who invested money, promoted the company on other websites and recruited other participants. Under a complicated formula, investors were issued "profit points" that grew every day.

Investments were capped at $10,000, but people could invest on behalf of their spouses, children or other relatives. Some mortgaged homes to raise their investment.

At first, ZeekRewards complied when investors sought to cash out. And that became the best ad of all: happy investors with their checks in Facebook photos.

People who didn't trust the mail traveled long distances to drop off checks at the cramped office building where security guards allowed only seven inside at a time. Employees collected money and wrote out receipts at the office cluttered with dozens of plastic mail bins stuffed with check-filled envelopes. To withdraw money, investors filed an online request ? or called ? and then had to wait for a check.

By the end of 2011, it seemed like everybody in Lexington was talking about ZeekRewards. Many saw it as a way to make extra cash to pay bills or help family.

"No one was in it to get rich," said Mary Bell, a 75-year-old seamstress from Lexington who scraped together money to invest.

Sarah Chavez wanted extra money for her daughter's frequent hospital visits for leukemia. Her husband worked in a factory, and they invested $7,000.

"It's hard to believe in something like that. But everyone told us it was a sure thing," she said.

Burks mostly kept to himself, and few locals knew anything about the quiet, balding man with thick glasses.

In the 1980s and early 1990s, the Shreveport, La., native toured nursing homes in the South as a magician with country singer David Houston. Burks moved to Lexington in the early 1990s because his wife was from the area.

In 2000, Burks ran for the state House as a Libertarian, but he collected only 330 votes.

Then he became a local celebrity.

Most afternoons, he ate lunch at the same downtown restaurant with an entourage of managers. Conference calls with investors were posted on YouTube. He produced glossy brochures touting the company.

"In addition to the mind-blowing savings, you can create more wealth than you have ever thought possible with ZeekRewards' geometrically progressive matric compensation plan," the brochure said.

Burks also hired some of the industry's top attorneys and analysts to promote his company.

The publicity paid off. When the Association of Network Marketing Professionals held its annual convention in March 2012, it called ZeekRewards the model of legal compliance.

___

But behind the scenes, there were troubling signs, according to documents, company emails and consumer complaints reviewed by the AP.

In early June, the state of Montana gave ZeekRewards the boot. Montana requires multilevel marketing companies to register. But ZeekRewards didn't submit any paperwork ? even after warnings, said Luke Hamilton, a spokesman for the attorney general's office.

"We started getting a lot of complaints," he said.

In August, a North Carolina employees' credit union warned customers not to invest in ZeekRewards because it was a "fraudulent company."

But regulators received complaints long before then.

In a Nov. 23, 2011, complaint filed with the North Carolina Attorney General's office, Wayne Tidderington of Florida called ZeekRewards an "illegal" Ponzi scheme. He said a relative had invested $8,000 and the company guaranteed a return of 125 percent every 90 days.

The attorney general's office can ask a judge to shut down a business because of deceptive trade practices. But it forwarded Tidderington's complaint to the secretary of state's office because it looked like it might involve securities. The secretary of state's office, however, declined to take action because it didn't believe it had the jurisdiction, spokeswoman Liz Proctor said.

The complaint died.

"I put it all together," Tidderington told the AP. "I gave them the roadmap. I said, 'Here's a snake. Here's the gun. Here's the bullets. Shoot the snake.' But they ignored me."

Over the next seven months, the attorney general's office received nearly a dozen more complaints.

But it wasn't until July 6 that it issued an order giving Burks until the end of the month to turn over all Zeek-related documents. He missed that deadline.

Kevin Anderson, senior deputy attorney general for consumer protection, insisted his agency correctly handled the case, saying his office receives thousands of complaints a year.

"We have to have more concrete evidence than a couple of consumer complaints before we go to court," he said.

The SEC received similar complaints during the same period, but the agency didn't begin its investigation until the summer.

SEC spokeswoman Christine D'Amico declined to comment on the investigation, except to say the agency took action "as soon as we believed we had sufficient evidence to obtain an emergency court order to halt the fraud."

___

Months later, people in Lexington are wondering what's next.

Kenneth Bell, the court-appointed receiver, said ZeekRewards may have taken in $800 million. So far, he's recovered $312 million. Hundreds of millions were paid out to investors. Just how much is missing? He doesn't know.

Myers said the community is still recovering ? but the wounds are deep. People are wondering why investigators didn't act more quickly and why no one, including Burks, has been charged.

"There are thousands and thousands of victims who might not have lost a penny had the government intervened more quickly," she said.

Source: http://news.yahoo.com/authorities-600m-scheme-incubated-nc-town-135809168.html

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Saturday, March 30, 2013

DNA: How to unravel the tangle

Mar. 29, 2013 ? A chromosome is rarely found in the shape we are used to seeing in biology books, that is to say the typical double rod shape (the X pattern, to put it simply). It is usually "diluted" in the nucleus and creates a bundle that under the microscope appears as a messy tangle. In the last few years such chaos, however, has been "measured" and scientists have unveiled their secret: the genes in the tangle are actually arranged in regions that may perform a functional role.

A research coordinated by the scientists at SISSA of Trieste has now developed and studied a numeric model of the chromosome that supports the experimental data and provides a hypothesis on the bundle's function.

A chromosome spends most of its life "diluted" in the nuclear cytoplasm. To the untrained eye it may look like a randomly entangled thread, yet biologists claim the opposite: although a chaotic component does exist in the bundle, experimental measurements have identified regions that tend to contain specific genes. Thanks to such measurements, researchers have obtained maps of the chromosome in its diluted form, the one in which the DNA transcription processes occur.

Cristian Micheletti, a physicist of SISSA, the International School for Advanced Studies of Trieste, has coordinated an international research team -- in which Marco Di Stefano and Angelo Rosa stand out -- that has devised an ingenious method which, on one hand, has allowed to verify the already known experimental measures and, on the other, to find data in support of a theory which explains why the DNA bundle is arranged in regions. "Employing the vast amount of publicly available data on gene expression, we have identified families of genes co-regulated within a chromosome" explains Micheletti. The co-regulated genes codify "in accord," but how such synchronization occurs is a mystery, since often the genes are located very far from one another on the DNA filament. "Two main hypotheses may be considered: either 'messengers' exist that travel back and forth from one gene to the other and coordinate the activity, or the DNA filament folding up inside the tangle brings the genes belonging to the same family physically close."

On the basis of the second assumption Micheletti and his colleagues have used the computer to induce the DNA numeric model to bring the co-regulated genes closer. "The outcome of the simulation has provided a map of chromosome arrangement that is very close to the one obtained through experimentation," explains Micheletti. "Besides, the model has successfully brought closer the genes belonging to the same family, as we had asked for, in 80% of cases, that is without too much effort, which corroborates the validity of the hypothesis and the effectiveness of the simulation."

The article was chosen by PLoS Computational Biology journal as the cover story for the March issue.

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The above story is reprinted from materials provided by Sissa Medialab, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Marco Di Stefano, Angelo Rosa, Vincenzo Belcastro, Diego di Bernardo, Cristian Micheletti. Colocalization of Coregulated Genes: A Steered Molecular Dynamics Study of Human Chromosome 19. PLoS Computational Biology, 2013; 9 (3): e1003019 DOI: 10.1371/journal.pcbi.1003019

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/5bCOx0FC-Ns/130329124420.htm

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The After Math: a million Z10s, the UnCarrier's new plan and a 16-button controller

Welcome to The After Math, where we attempt to summarize this week's tech news through numbers, decimal places and percentages

The After Math Blackberry ships a million Z10s, more PlayStation 4 details and a 16button controller

This week, there's been a mixed bag of interesting news numbers, from T-Mobile's New York event and the company's new perspective on the phone network business, to San Francisco (again) for the Games Developers Conference. We also got to take a look at BlackBerry's first financial results since the name change and its BB10 launch.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/M5lkq3Q1v5A/

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Attacks leave more than 50 dead in central Nigeria

JOS, Nigeria (AP) ? Attacks on villages surrounding a central Nigerian city at the heart of unrest between Christians and Muslims have killed more than 50 people this week, officials said Saturday, as authorities pleaded for peace over the Easter holiday.

The attacks around Jos, a city in Nigeria's fertile central belt, come as a string of unsolved killings continue to plague the region that has seen thousands killed in massacres in recent years. While a combined police and military presence still patrols Jos and other parts of Plateau state, many of the villages attacked sit in remote, rural corners of the area that sometimes have only a single police officer on duty.

The most recent killings happened Friday night in the Barkin Ladi area, said Lt. Jude Akpa, a military spokesman. Attackers raided a village called Bokkos and killed nine people, fleeing before soldiers arrived, Akpa said. Emmanuel Lohman, a government official there, said gunmen armed with assault rifles struck a village called Ratas and opened fire in the night while many there were sleeping.

Witnesses said the shooting lasted for almost two hours before the attackers fled. The Christian villagers there, who farm the fertile soils of Plateau state, blamed nomadic Hausa-Fulani cattle herdsmen for the attack. Such attacks remain common as Christian farmers clash with the herdsmen over land and grazing rights. Other attacks often are rooted in disputes over political and economic power in the region, which sits on the divide of Nigeria's predominantly Muslim north and largely Christian south.

Muhammadu Nura, the state secretary of a cattle breeders association, said Hausa-Fulani people had been killed in "reprisals," but denied herders were involved the attacks.

In recent days, witnesses and government officials say more than 50 people have been killed in attacks. That includes an assault Wednesday on a village in the Riyom local government area that killed 28 people and an attack Thursday in the Bokkos local government area that killed 18 civilians. The military said it killed six while trying to repel attackers in Thursday's assault.

Jos and surrounding Plateau state have been torn apart in recent years by violence pitting its different ethnic groups and major religions ? Christianity and Islam ? against each other. Human Rights Watch says at least 1,000 people were killed in communal clashes around Jos in 2010, attacks that saw whole villages killed. While major massacres haven't happened in the last few years, so-called "silent killings" continue and the two faiths have moved into different areas of the city.

Major attacks by Islamic extremists, including car bombings, also have hit the area in recent years as Nigeria's weak central government appears unable to stop the killings. With Easter on Sunday, government officials urged those living in Jos and the surrounding villages to be calm and peaceful during the holiday.

Plateau state Gov. Jonah Jang, a Christian long criticized for not doing more to stop the killings, said his government will continue to work for peace and prosperity in an area long beset by tension.

"Christians must claim this season, which symbolizes hope, by rededicating their lives to the teachings and path of Christ so as not to lose eternity," he said in a statement.

___

Associated Press writer Jon Gambrell in Lagos, Nigeria, contributed to this story.

Source: http://news.yahoo.com/attacks-leave-more-50-dead-central-nigeria-134442722.html

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Newcastle Historical Society website goes live : Newcastle News ...

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Home / Local News / Newcastle Historical Society website goes live

NEW?? 2:10 p.m. March 28, 2013

In an effort to increase its presence, the Newcastle Historical Society has launched a website, complete with information about the city?s rich history and photographs of mementos from Milt Swanson?s personal museum.

The website, www.newcastlewahistory.org, also has membership information and a space to sign up to volunteer with the organization.

The Newcastle Historical Society meets the first Thursday every month at 4 p.m. at City Hall. The group?s April 4 meeting will be a birthday celebration for Swanson, who turns 95 on March 29.

Written by Staff ? Filed Under Local News?

Copyright 2010 by Issaquah Press Inc. All rights reserved. This material may not be published, rewritten or redistributed without permission. E-mail editor@isspress.com

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Source: http://www.newcastle-news.com/2013/03/28/newcastle-historical-society-website-goes-live

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Friday, March 29, 2013

Rebel group: Congo warlord wanted control of M23

KAMPALA, Uganda (AP) ? A spokesman for a Congolese rebel group said Thursday that rebel fighters in the M23 group were trying to kill warlord Bosco Ntaganda, who fled Congo and turned himself in to a U.S. Embassy last week before being transferred to the International Criminal Court.

Rene Abandi said Ntaganda tried to "influence the chain of command" but went too far when he challenged M23 military chief Sultani Makenga.

Fierce clashes between rival factions of M23 earlier this month left Makenga with the upper hand and triggered the chain of events that forced Ntaganda to give up his freedom after nearly seven years as a fugitive warlord wanted by the International Criminal Court for war crimes.

On March 18, days after losing a fight with an M23 faction loyal to Makenga, Ntaganda showed up the U.S. Embassy in Rwanda and asked to be transferred to the ICC. This week he made his first court appearance at The Hague.

"What shocked Gen. Makenga was this fight which was the stupidity of Ntaganda," Abandi said from the rebel stronghold of Bunagana in eastern Congo. "After that our goal was just to neutralize him because he was causing problems. He tried to influence the movement from outside."

It remains unclear how Ntaganda ended up in Kigali, the Rwandan capital, or what motivated him to surrender. Abandi said they believe he sneaked into Rwanda through a jungle crossing that is not heavily policed by Rwandan border officials.

"He passed through an area where there is no official border, near the Virunga National Park," Abandi said.

Ntaganda, the boss of a rebel group that was M23's precursor, had lived a relatively free life in the eastern Congolese town of Goma, allegedly occupying a villa there and even playing tennis. An ethnic Tutsi born in Rwanda, he was first indicted in 2006 by the ICC for allegedly recruiting child soldiers during a 2002-03 conflict in Congo's eastern Ituri province. A second arrest warrant issued last July accused him of crimes including murder, rape, sexual slavery and pillaging.

For M23, according to Abandi, Ntaganda's exit from the Congo left the group stronger even as it dimmed hopes for a peace process that had been under way in the Ugandan capital, Kampala, since December. Those talks are now on hold, with both the Congolese and M23 delegations saying they are holding consultations.

M23 had split at the end of February following a dispute among the leaders of the movement when Makenga dismissed the political head of the movement, Jean-Marie Runiga. Both men then formed their own factions, which have been fighting since.

The fight between M23 factions divided the group's peace delegation and led to the ouster of its leader, Francois Rucogoza, who is now afraid to return home, according to Chrispus Kiyonga, the talks' Ugandan mediator.

M23 is made up of hundreds of soldiers who deserted the Congolese army last April. The rebels accuse Congo's government of failing to honor the terms of a 2009 peace deal that incorporated them into the national army. In turn, the government accuses M23 of violating that agreement by taking up arms instead of talking. Even as human-rights groups charge M23 with numerous human-rights violations in eastern Congo, regional leaders have urged the Congolese government to listen to the "legitimate grievances" of M23.

According to Abandi, Ntaganda's side spread rumors that Makenga was secretly doing business with the government in Kinshasa even as a delegation from M23 negotiated peace with the Congolese government in neighboring Uganda. When those claims failed to sow discord among the fighters, he said, Ntaganda then tried to challenge Makenga militarily.

"Gen. Makenga won the fight," he said. "The morale of the troops is now high. They are very proud of their general."

There is no international arrest warrant out for Makenga, but he is under U.N. sanctions and rights groups say he has committed crimes similar to those attributed to Ntaganda.

Source: http://news.yahoo.com/rebel-group-congo-warlord-wanted-control-m23-131648912.html

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HIV antibodies that are worth the wait

Friday, March 29, 2013

An effective vaccine against HIV-1 remains elusive, but one promising strategy focuses on designer antibodies that have much broader potency than most normal, exquisitely specific antibodies. These broadly neutralizing antibodies (bNAbs) can handle the high mutation rate of HIV particles that makes normal, very specific antibodies useless within a short space of time. A study published by Cell Press on March 28th in the journal Cell reveals surprising mutations in these antibodies that are crucial for strong protection against HIV-1. The findings could guide efforts to design better HIV-1 vaccines.

"This study demonstrates a fundamental aspect of antibodies' function and development that was not fully appreciated before," says study author Ron Diskin of the Weizmann Institute of Science. "We show that it will be important to pay more attention to previously ignored regions of antibodies to design effective vaccines."

Scientists have recently found that some HIV-1-infected individuals produce bNAbs naturally several years after infection. Animal studies have shown that these antibodies are very effective at protecting against and controlling HIV-1 infection, but what makes them so effective was unknown. Antibodies are Y-shaped molecules, and most variation is found at the two tips of the Y, called the complementarity determining regions, where antibodies make direct contact with the virus. On the other hand, relatively few mutations have been found in framework regions (the bottom half of the Y), which maintain the structural integrity of the antibody. Until now, the role of framework region mutations had been unclear.

The study, led by Michel Nussenzweig of Rockefeller University and Pamela Bjorkman of the California Institute of Technology, has revealed that HIV-1-fighting bNAbs accumulate mutations in framework regions, in contrast to most antibodies. Surprisingly, these mutations strengthened the antibodies' antiviral activity while conserving key structural features. The researchers suggest that several years are required for infected individuals to produce these potent antibodies because it takes time for the right combination of various mutations to accumulate.

"Our study shows that the immune system has a variety of ways to make effective antibodies and that mutations in antibody framework regions, which are usually not changed when antibodies mutate to increase their efficacy, are required for anti-HIV antibodies," Bjorkman says. "This has clear implications for efforts to raise effective antibodies for the next generation of HIV vaccines."

###

Cell Press: http://www.cellpress.com

Thanks to Cell Press for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127512/HIV_antibodies_that_are_worth_the_wait

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Forbes values Yankees at $2.3 billion

(AP) ? Forbes estimated the New York Yankees have the highest value in Major League Baseball for the 16th straight year at $2.3 billion, and the average for an MLB team increased by 23 percent in the last year to $744 million.

The magazine said Wednesday the Yankees' value increased from $1.85 billion last year.

The Los Angeles Dodgers are second in MLB at $1.62 billion ? nearly $400 million below the price paid for the team last May when a group headed by Mark Walter, Stan Kasten and Magic Johnson bought the franchise from Frank McCourt.

Forbes valued Boston third at $1.3 billion, followed by the Chicago Cubs ($1 billion), Philadelphia ($893 million), the New York Mets ($811 million), San Francisco ($786 million), Texas ($764 million), the Los Angeles Angels ($718 million) and St. Louis ($716 million).

The bottom five are Tampa Bay ($451 million), Kansas City ($457 million), Oakland ($468 million), Pittsburgh ($479 million) and Miami ($520 million).

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-03-27-BBO-Forbes-MLB-Team-Valuations/id-d3d772561fc743c6973292cc861114a6

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Thursday, March 28, 2013

ZTE Posts Second-Straight Quarter Loss, To Round Off First Annual Loss

zte-logo-001As it already warned, ZTE posted its second-straight quarterly loss, due to contract delays and falling handset sales in China. It made a net loss of 1.14 billion yuan ($183 million) in the three months ended Dec. 31, compared with its net income of 991.16 million yuan a year prior. Sales in the fourth quarter also fell 16 percent to 23.5 billion yuan ($3.78 billion). This rounds off its first yearly loss, at 2.84 billion yuan ($456 million). The company blamed the decrease in profit margin on low-margin contracts in emerging markets like Africa, South America and Asia, as well as its home market of China. ZTE has spent the last 20 years aggressively expanding overseas, but often at the cost of profitability because of its slim profit margins as it undercuts European equipment makers in emerging markets such as India. It recently said it will try to cut costs and make a profit in the first quarter by focusing on developed markets, instead. ZTE has been lagging behind fellow Chinese rival, Huawei Technologies. The former recently announced it will increase its investment in 4G infrastructure, in order to catch up with Huawei, as the two compete for most 4G contracts from the three major carriers in China?China Mobile, China Unicom and China Telecom.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/jaZT_6X9KJY/

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Google posts Android 4.2.x factory images for Sprint and Verizon Galaxy Nexus models

Google posts Android 42x factory images for Sprint and Verizon Galaxy Nexus models

Many would call the HSPA+ Galaxy Nexus the only true Nexus of its era. Still, Google is willing to treat the CDMA versions as equals, and it just posted factory images with the latest available Jelly Bean builds for those devices. Anyone with a Verizon model can now flash with Android 4.2.2 if their existing OS install ever goes awry; Sprint users aren't quite on an equal plane, but do get a 4.2.1 image to work from. Relevant driver binaries are also available. Whether you're a custom ROM creator looking for a starting point or just want a fallback for any risky experiments, the relevant source links should have what you need.

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Via: Droid-Life

Source: Google Developers (1), (2)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/h4fqXes7bO0/

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Is the T-Mobile iPhone a Good Deal?

Is the T-Mobile iPhone a Good Deal?
The iPhone is now available on all major U.S. carriers. But is T-Mobile?s unique pricing plan worth it?

Source: http://feedproxy.google.com/~r/GearFactor/~3/GXAh_6sfSFY/

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In snub to Assad, opposition takes Syria's Arab summit seat

By Sami Aboudi and Yara Bayoumy

DOHA (Reuters) - To applause from Arab heads of state, a foe of Bashar al-Assad took Syria's vacant seat at an Arab summit on Tuesday, deepening the president's diplomatic isolation and diverting attention from rifts among his opponents.

Speaking at an annual gathering of Arab leaders in the Gulf state of Qatar, Moaz Alkhatib said he had asked U.S. Secretary of State John Kerry for American forces to help defend rebel-controlled northern parts of Syria with Patriot surface-to-air missiles now based in Turkey. NATO swiftly rebuffed the idea.

"It was a historic meeting," said opposition spokesman Yaser Tabbara. "It's a first step towards acquiring full legal legitimacy."

The 22-nation League is set to support giving military aid to Syrian rebels. A draft summit communique offered some of its toughest language yet against Assad, affirming member states had a right to offer assistance "including military, to support the steadfastness of the Syrian people and the Free Army".

Alkhatib said the United States, which has given non-military aid to Syrian rebels, should play a bigger role in helping end the two-year-old conflict in Syria, blaming Assad's government for what he called its refusal to solve the crisis.

"I have asked Mr. Kerry to extend the umbrella of the Patriot missiles to cover the Syrian north and he promised to study the subject," he said, referring to NATO Patriot missile batteries sent to Turkey last year to protect Turkish airspace.

"We are still waiting for a decision from NATO to protect people's lives, not to fight but to protect lives," he added, addressing a body that barred Assad's government in late 2011.

Responding to Alkhatib's remarks, an official of the Western military alliance at its headquarters in Brussels said: "NATO has no intention to intervene militarily in Syria."

Turkey, which reported a mortar landing harmlessly on its border on Tuesday, said it was up to the rest of NATO to decide if members wanted to expand the remit of the Patriot batteries.

Michael Stephens, a researcher based in Qatar for Britain's Royal United Services Institute, said acceding to Alkhatib's request would effectively put NATO at war with Damascus.

DEFENSIVE DEPLOYMENT

NATO's current deployment of three Patriot missile batteries in southern Turkey is intended to be purely defensive. The Patriots are designed to shoot down hostile missiles in mid-air.

Alkhatib, a Sunni Muslim cleric, took Syria's seat at the summit for the first time despite announcing on Sunday that he would step down as leader of the Syrian National Coalition.

Behind him sat Ghassan Hitto, the prime minister of a provisional opposition government that plans to run rebel-held area, and fellow senior opposition official George Sabra.

Alkhatib made a blunt call on other Arab leaders to "fear God in dealing with your people" and free political prisoners - a departure from anodyne tradition at the League.

But he also criticized what he called Western failure to bring an end to the conflict, and said an influx of foreign Islamist fighters should not be used by the West as a pretext to deny Syrians meaningful help. He denounced the presence in Syria of Iranians and Russians he said were backing the government.

In his opening speech as host, Qatar's Sheikh Hamad bin Khalifa al-Thani urged the U.N. Security Council to stop the "oppression and repression of the people" in Syria, halt the bloodshed and "present those responsible for these crimes against their people to international justice".

The United Nations says about 70,000 people have been killed in a conflict that began with peaceful anti-Assad protests and turned into an increasingly sectarian armed insurrection.

The war in Syria has divided world powers, paralyzing action at the Security Council. The Arab world is also split, with Saudi Arabia and Qatar the most fervent foes of Assad, and Iraq, Algeria and Lebanon the most resistant to calls for his removal.

The conflict echoes sectarian strains between Sunni Muslims, notably in the Gulf, and Shi'ites, mainly in Iraq, Lebanon and non-Arab Iran, whose faith is close to Assad's Alawite minority.

Syrian rebels again fired mortar rounds into central Damascus on Tuesday. State television said several people had been wounded by "terrorist" mortar bombs that landed in the Syrian Arab News Agency SANA compound in the Baramkeh district.

State television said a suicide car bomber killed and wounded several people in northeastern Damascus, although opposition activists said the blast could have been a mortar.

Syrian state TV did not cover the Arab League meeting in Qatar, airing a program on makeup for women instead.

A group of pro-Assad hackers signing themselves the Syrian Electronic Army claimed an attack on an Arab League website that directed readers to a picture of Assad and derided the League's Egyptian secretary-general for his "loyalty to the sheikhs".

INTERNAL DISARRAY

Alkhatib's decision to quit, which he blamed on the world's failure to back the armed revolt against Assad also appeared to be motivated by internal disputes in the alliance. It undermined the alliance's claim to provide a coherent alternative to Assad.

Liberals saw it as a protest against what they view as the rising influence of hardline Islamists in the Qatari-backed umbrella group set up in Doha in November.

Jane Kinninmont, of Britain's Chatham House think-tank, said Qatar and the other Gulf states had been frustrated that the United States in particular and also European powers had not done more to help the Syrian opposition.

"The Gulf countries contrast this to the Iraq war which many of them were quite dubious about," she said. "And they see a U.S. that's far less interventionist today, even though there's a much greater case for and immediate humanitarian need."

(Additional reporting by Mirna Sleiman and William Maclean, Omar Fahmy in Cairo, Oliver Holmes and Erika Solomon in Beirut, Gulsen Solker in Ankara and Adrian Croft in Brussels; Writing by Alistair Lyon; Editing by Alastair Macdonald)

Source: http://news.yahoo.com/syria-opposition-expected-syria-seat-arab-summit-080255252.html

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Wednesday, March 27, 2013

DNA test reveals cancer risk markers

More than 80 genetic markers that can increase the risk of developing breast, prostate or ovarian cancer have been found in the largest study of its kind.

The DNA of 200,000 people - half of them with cancer and half without - was compared, revealing an individual's inherited risk of the diseases.

British scientists, who led the research, believe it could lead to a DNA screening test within five years.

They also hope it will boost knowledge of how the cancers develop.

The research was led by scientists at the University of Cambridge and the Institute of Cancer Research (ICR) in London and funded by Cancer Research UK (CRUK) and the Wellcome Trust.

The main findings are published in five articles in the journal Nature Genetics.

Study author Prof Doug Easton said: "We're on the verge of being able to use our knowledge of these genetic variations to develop test that could complement breast cancer screening and take us a step closer to having an effective prostate cancer screening programme."

Continue reading the main story

Each of us is born with a genetic hand of cards passed down from our parents.

This is called our genome and is made of three billion pieces of code made of just chemical letters: A, C, T and G.

A single nucleotide polymorphism is a single letter difference in DNA between individuals.

We each have millions of variations and most of these seem benign. This study looked at more than 100,000 common differences found in at least one in 10 people.

By comparing cancer patients with healthy controls the scientists could identify genetic spelling mistakes that occurred repeatedly in the cancer group.

Forty nine new single nucleotide polymorphisms (Snps) were found associated with breast cancer, bringing the total identified to 76.

For prostate cancer, 23 new markers were found, bringing the total to 78. And for ovarian cancer, eight new regions were found, bringing the total to 12.

Inherited cancer risk

The scientists looked for common genetic variations - known as single nucleotide polymorphisms (Snps) - linked to the three cancers.

Each alteration raised the risk of cancer by a small amount. However, a small minority of men with lots of the markers could see their risk of prostate cancer increase more than fourfold and for women the breast cancer risk increase threefold.

By contrast, the test can also identify those with a smaller than average risk of developing the cancers.

A woman's lifetime risk of breast cancer is one in eight, but among the 1% with lots of these newly identified genetic variations the risk rises to one in two.

The test could also help the one in 300 woman who carry a faulty gene known as BRCA1 or BRCA2. Two-thirds of them will develop breast cancer before the age of 80 and 45% who carry BRCA1 will get ovarian cancer.

At present the options to reduce their risks are limited - a double mastectomy or having their ovaries removed.

By combining the gene test for BRCA1 and BRCA2 with this extra genetic information, women who have a high number of the newly identified markers could find they have a nearly 100% risk of getting breast cancer.

In contrast, those with the protective versions of the genetic changes could see their risk drop to as low as 20%.

Dr Antonis Antoniou, CRUK senior fellow at the University of Cambridge, said: "Our research puts us on the verge of being able to give women a much more accurate picture of how likely they are to develop breast or ovarian cancer and would help to guide them about the most appropriate type and time of prevention or monitoring options for them."

Prostate

For men, the lifetime risk of developing prostate cancer is one in eight. But for 1% who carry a significant number of genetic alterations, the risk rises to one in two.

Unlike for breast cancer, there is no screening programme for the disease.

The prostate-specific antigen or PSA test, looks for protein markers in the blood and high levels may be an indicator or prostate cancer. But it is unreliable.

Furthermore, about two-thirds of men who get prostate cancer have a slow-growing "indolent" form of the disease that will not kill them.

Treatment options include prostate removal, radiotherapy and hormone treatment, But for every life saved through treatment for prostate cancer, it is thought that between 12 to 48 men are treated unnecessarily. Many patients opt for "watchful waiting", monitoring the cancer.

Sixteen of the 23 newly identified genetic markers are associated with aggressive forms of the disease so may help clinicians and patients decide on the best form of treatment.

Prof Ros Eeles, from the ICR, said: "These results are the single biggest leap forward in finding the genetic causes of prostate cancer.

"If further studies show such men benefit from regular screening, we could have a big impact on the number of people dying from the disease, which is still far too high."

Source: http://www.bbc.co.uk/news/health-21945812#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Tuesday, March 26, 2013

Galaxy S4 hits T-Mobile on May 1 for $99

Samsung Galaxy S4

Don't let this get lost in the shuffle this morning, folks. T-Mobile has become the first U.S. operator to give a date to its Galaxy S4. You'll be able to pick up Samsung's latest and greatest May 1 for a $99 "down payment." 

The "down payment" thing is new, though it's not all that different from the usual "on contract" qualifier we usually use. You pay a little up front, and you end up paying off the phone over a number of months. It's all part of T-Mobile's new "Simple Choice" plans unveiled this morning in New York City.

The important thing here is that we finally have a hard and firm date on what's sure to be one of the hottest phones of the year. May 1. Mark it, dude.



Source: http://feedproxy.google.com/~r/androidcentral/~3/qB1mC6WYcms/story01.htm

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Glass-blowers at a nano scale

Mar. 25, 2013 ? EPFL researchers are using the electrical properties of a scanning electron microscope to change the size of glass capillary tubes -- Their method has already been patented as it could pave the way to many novel applications.

Have you ever thrown into the fire -- even if you shouldn't have -- an empty packet of crisps? The outcome is striking: the plastic shrivels and bends into itself, until it turns into a small crumpled and blackened ball. This phenomenon is explained by the tendency of materials to pick up their original features in the presence of the right stimulus. Hence, this usually happens when heating materials that were originally shaped at high temperatures and cooled afterwards.

EPFL researchers realized that this phenomenon occurred to ultrathin quartz tubes (capillary tubes) under the beam of a scanning electron microscope. "This is not the original microscope's purpose. The temperature increase is explained by an accumulation of electrons in the glass. Electrons accumulate because glass is a non-conductive material." explains Lorentz Steinbock, researcher at the Laboratory of Nanoscale Biology and co-author of a paper on this subject published in Nano Letters.

As the glass shrinks, it can be seen live on the microscope screen. "It's like a glass-blower. Thanks to the possibilities provided by the new microscope at EPFL's Center of Micronanotechnology (MIC), the operator can adjust the microscope's voltage and electric field strength while observing the tube's reaction. Thus, the person operating the microscope can very precisely control the shape he wants to give to the glass," says Aleksandra Radenovic, tenure-track assistant professor in charge of the laboratory.

At the end of this process, the capillary tube's ends are perfectly controllable in diameter, ranging from 200 nanometers to fully closed. The scientists tested their slimmed down tubes in an experiment aiming to detect DNA segments in a sample. The test sample was moved from one container to another on a microfluidic chip. Whenever a molecule crossed the "channel" connecting the containers, the variation of the ion current was measured. As expected, the EPFL team obtained more accurate results with a tube reduced to the size of 11 nm than with standard market models. "By using a capillary tube costing only a few cents, in five minutes we are able to make a device that can replace "nano-channels" sold for hundreds of dollars!" explains Aleksandra Radenovic.

These nano-fillers have a potential beyond laboratory usage. "We can imagine industrial applications in ultra-high precision printers, as well as opportunities in surgery, where micro-pipettes of this type could be used at a cell's scale," says the researcher.

For the time being, the method for manufacturing nano-capillary tubes is manual, the transition to an industrial scale will take some time. However, the researchers have been able to demonstrate the concept behind their discovery and have registered a patent. Therefore, the road is already paved.

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The above story is reprinted from materials provided by Ecole Polytechnique F?d?rale de Lausanne, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. L. J. Steinbock, J. F. Steinbock, A. Radenovic. Controllable Shrinking and Shaping of Glass Nanocapillaries under Electron Irradiation. Nano Letters, 2013; : 130318124758001 DOI: 10.1021/nl400304y

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/MagwEdbjdsE/130325111156.htm

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Kerry in Paris to talk Syria with French

Mar 26 (Reuters) - Leading money winners on the 2013 PGATour on Monday (U.S. unless stated): 1. Tiger Woods $3,787,600 2. Brandt Snedeker $2,859,920 3. Matt Kuchar $2,154,500 4. Steve Stricker $1,820,000 5. Phil Mickelson $1,650,260 6. Hunter Mahan $1,553,965 7. John Merrick $1,343,514 8. Dustin Johnson $1,330,507 9. Russell Henley $1,313,280 10. Kevin Streelman $1,310,343 11. Keegan Bradley $1,274,593 12. Charles Howell III $1,256,373 13. Michael Thompson $1,254,669 14. Brian Gay $1,171,721 15. Justin Rose $1,155,550 16. Jason Day $1,115,565 17. Chris Kirk $1,097,053 18. ...

Source: http://news.yahoo.com/kerry-paris-talk-syria-french-184608897.html

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Harvard's Wyss Institute awarded DARPA contract to further advance sepsis therapeutic device

Harvard's Wyss Institute awarded DARPA contract to further advance sepsis therapeutic device [ Back to EurekAlert! ] Public release date: 25-Mar-2013
[ | E-mail | Share Share ]

Contact: Kristen Kusek
kristen.kusek@wyss.harvard.edu
617-432-8266
Wyss Institute for Biologically Inspired Engineering at Harvard

The Wyss Institute for Biologically Inspired Engineering at Harvard University announced today that it was awarded a $9.25 million contract from the Defense Advanced Research Projects Agency (DARPA) to further advance a blood-cleansing technology developed at the Institute with prior DARPA support, and help accelerate its translation to humans as a new type of sepsis therapy.

The device will be used to treat bloodstream infections that are the leading cause of death in critically ill patients and soldiers injured in combat.

To rapidly cleanse the blood of pathogens, the patient's blood is mixed with magnetic nanobeads coated with a genetically engineered version of a human blood 'opsonin' protein that binds to a wide variety of bacteria, fungi, viruses, parasites, and toxins. It is then flowed through microchannels in the device where magnetic forces pull out the bead-bound pathogens without removing human blood cells, proteins, fluids, or electrolytes much like a human spleen does. The cleansed blood then flows back to the patient.

"In just a few years we have been able to develop a suite of new technologies, and to integrate them to create a powerful new device that could potentially transform the way we treat sepsis," said Wyss founding director and project leader, Don Ingber, M.D., Ph.D. "The continued support from DARPA enables us to advance our device manufacturing capabilities and to obtain validation in large animal models, which is precisely what is required to enable this technology to be moved towards testing in humans."

The team will work to develop manufacturing and integration strategies for its core pathogen-binding opsonin and Spleen-on-a-Chip fluidic separation technologies, as well as a novel coating technology called "SLIPS," which is a super-hydrophobic coating inspired from the slippery surface of a pitcher plant that repels nearly any material it contacts. By coating the inner surface of the channels of the device with SLIPS, blood cleansing can be carried out without the need for anticoagulants to prevent blood clotting.

In addition to Ingber, the multidisciplinary team behind this effort includes Wyss core faculty and Harvard School of Engineering and Applied Science faculty member Joanna Aizenberg, Ph.D., who developed the SLIPS technology; Wyss senior staff member Michael Super, PhD., who engineered the human opsonin protein; and Mark Puder, M.D., Ph.D., Associate Professor of Pediatric Surgery at Boston Children's Hospital and Harvard Medical School who will be assisting with animal studies.

###

IMAGES AVAILABLE.

About the Wyss Institute for Biologically Inspired Engineering at Harvard University

The Wyss Institute for Biologically Inspired Engineering at Harvard University uses Nature's design principles to develop bioinspired materials and devices that will transform medicine and create a more sustainable world. Working as an alliance among Harvard's Schools of Medicine, Engineering, and Arts & Sciences, and in partnership with Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Boston Children's Hospital, Dana Farber Cancer Institute, Massachusetts General Hospital, the University of Massachusetts Medical School, Spaulding Rehabilitation Hospital, Boston University and Tufts University, the Institute crosses disciplinary and institutional barriers to engage in high-risk research that leads to transformative technological breakthroughs. By emulating Nature's principles, Wyss researchers are developing innovative new engineering solutions for healthcare, energy, architecture, robotics, and manufacturing. These technologies are translated into commercial products and therapies through collaborations with clinical investigators, corporate alliances, and new start-ups. The Wyss Institute recently won the prestigious World Technology Network award for innovation in biotechnology.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Harvard's Wyss Institute awarded DARPA contract to further advance sepsis therapeutic device [ Back to EurekAlert! ] Public release date: 25-Mar-2013
[ | E-mail | Share Share ]

Contact: Kristen Kusek
kristen.kusek@wyss.harvard.edu
617-432-8266
Wyss Institute for Biologically Inspired Engineering at Harvard

The Wyss Institute for Biologically Inspired Engineering at Harvard University announced today that it was awarded a $9.25 million contract from the Defense Advanced Research Projects Agency (DARPA) to further advance a blood-cleansing technology developed at the Institute with prior DARPA support, and help accelerate its translation to humans as a new type of sepsis therapy.

The device will be used to treat bloodstream infections that are the leading cause of death in critically ill patients and soldiers injured in combat.

To rapidly cleanse the blood of pathogens, the patient's blood is mixed with magnetic nanobeads coated with a genetically engineered version of a human blood 'opsonin' protein that binds to a wide variety of bacteria, fungi, viruses, parasites, and toxins. It is then flowed through microchannels in the device where magnetic forces pull out the bead-bound pathogens without removing human blood cells, proteins, fluids, or electrolytes much like a human spleen does. The cleansed blood then flows back to the patient.

"In just a few years we have been able to develop a suite of new technologies, and to integrate them to create a powerful new device that could potentially transform the way we treat sepsis," said Wyss founding director and project leader, Don Ingber, M.D., Ph.D. "The continued support from DARPA enables us to advance our device manufacturing capabilities and to obtain validation in large animal models, which is precisely what is required to enable this technology to be moved towards testing in humans."

The team will work to develop manufacturing and integration strategies for its core pathogen-binding opsonin and Spleen-on-a-Chip fluidic separation technologies, as well as a novel coating technology called "SLIPS," which is a super-hydrophobic coating inspired from the slippery surface of a pitcher plant that repels nearly any material it contacts. By coating the inner surface of the channels of the device with SLIPS, blood cleansing can be carried out without the need for anticoagulants to prevent blood clotting.

In addition to Ingber, the multidisciplinary team behind this effort includes Wyss core faculty and Harvard School of Engineering and Applied Science faculty member Joanna Aizenberg, Ph.D., who developed the SLIPS technology; Wyss senior staff member Michael Super, PhD., who engineered the human opsonin protein; and Mark Puder, M.D., Ph.D., Associate Professor of Pediatric Surgery at Boston Children's Hospital and Harvard Medical School who will be assisting with animal studies.

###

IMAGES AVAILABLE.

About the Wyss Institute for Biologically Inspired Engineering at Harvard University

The Wyss Institute for Biologically Inspired Engineering at Harvard University uses Nature's design principles to develop bioinspired materials and devices that will transform medicine and create a more sustainable world. Working as an alliance among Harvard's Schools of Medicine, Engineering, and Arts & Sciences, and in partnership with Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Boston Children's Hospital, Dana Farber Cancer Institute, Massachusetts General Hospital, the University of Massachusetts Medical School, Spaulding Rehabilitation Hospital, Boston University and Tufts University, the Institute crosses disciplinary and institutional barriers to engage in high-risk research that leads to transformative technological breakthroughs. By emulating Nature's principles, Wyss researchers are developing innovative new engineering solutions for healthcare, energy, architecture, robotics, and manufacturing. These technologies are translated into commercial products and therapies through collaborations with clinical investigators, corporate alliances, and new start-ups. The Wyss Institute recently won the prestigious World Technology Network award for innovation in biotechnology.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/wifb-hwi032513.php

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Sunday, March 24, 2013

Musharraf returns to Pakistan intent on comeback

Former Pakistani President Pervez Musharraf, salutes the crowd, upon his arrival to Karachi airport, Pakistan, Sunday, March 24, 2013. Former Pakistani President Pervez Musharraf ended more than four years in self-exile Sunday with a flight to his homeland, seeking a possible political comeback in defiance of judicial probes and death threats from Taliban militants. (AP Photo/Shakil Adil)

Former Pakistani President Pervez Musharraf, salutes the crowd, upon his arrival to Karachi airport, Pakistan, Sunday, March 24, 2013. Former Pakistani President Pervez Musharraf ended more than four years in self-exile Sunday with a flight to his homeland, seeking a possible political comeback in defiance of judicial probes and death threats from Taliban militants. (AP Photo/Shakil Adil)

Former Pakistani President Pervez Musharraf, center, surrounded by guards, upon his arrival to Karachi airport, Pakistan, Sunday, March 24, 2013. Former Pakistani President Pervez Musharraf ended more than four years in self-exile Sunday with a flight to his homeland, seeking a possible political comeback in defiance of judicial probes and death threats from Taliban militants. (AP Photo/Shakil Adil)

Mir Hazar Khan Khoso, center, nominated for Pakistan's caretaker prime minister, waves as he arrives to brief members of the media in Islamabad, Pakistan, Sunday, March 24, 2013. Pakistan's election commission has chosen a former high court chief justice Khoso nominated by the country's outgoing ruling party to serves as caretaker prime minister in the run up to a historic national election this spring. (AP Photo/Anjum Naveed)

Pakistani police officers stand guard outside the room of Mir Hazar Khan Khoso, not pictured, nominated for Pakistan's caretaker prime minister, in Islamabad, Pakistan, Sunday, March 24, 2013. Pakistan's election commission has chosen a former high court chief justice Khoso nominated by the country's outgoing ruling party to serves as caretaker prime minister in the run up to a historic national election this spring. (AP Photo/Anjum Naveed)

Mir Hazar Khan Khoso, nominated for Pakistan's caretaker prime minister, talks to media in Islamabad, Pakistan, Sunday, March 24, 2013. Pakistan's election commission has chosen a former high court chief justice Khoso nominated by the country's outgoing ruling party to serves as caretaker prime minister in the run up to a historic national election this spring. (AP Photo/Anjum Naveed)

KARACHI, Pakistan (AP) ? Former President Pervez Musharraf returned home Sunday hoping to make a political comeback despite Taliban death threats and looming arrest warrants. But judging by the lackluster crowd at the airport to greet him, his biggest challenge could be his waning popularity.

His return comes as Pakistan is poised to transition from one democratically elected government to another ? a first for a country that has experienced three coups since its 1947 inception. After years on the margins of Pakistani politics, Musharraf is seeking to rebuild his image, hoping to capitalize on an electorate frustrated with five years of rising inflation, rolling blackouts and security problems.

Musharraf, a four-star general who was chief of the army, took power in a 1999 coup and his military-led regime steered the country for nearly a decade until he was forced to step down in 2008 as president. Confronted with mounting criticism and widespread protests after he tried to dismiss a popular chief justice, he left facing impeachment by the newly elected parliament.

He later left the country and has been living between London and Dubai ever since.

The former Pakistani strongman had promised to return to his homeland many times before. He finally followed through, boarding a plane in Dubai with supporters and journalists and flying to the southern port metropolis of Karachi, the largest city in the nation.

Stepping out of the terminal, surrounded by police and supporters, he portrayed himself as a savior seeking to return the country to the prosperity and stability that supporters say marked his presidency.

"I have come back for you. I want you to get back the Pakistan that I had left when we used to feel proud in ourselves," he said.

Musharraf represents a polarizing force that could further complicate Pakistan's attempt to hold parliamentary elections on May 11. The country passed another milestone Sunday when the election commission appointed a caretaker prime minister to run the government ahead of elections, a step that is designed to promote electoral independence.

Musharraf's supporters, including elements of the military and members of Pakistan's influential expatriate communities, consider him a strong leader whose voice could help stabilize the country. Nostalgia for Musharraf's days in power was evident among members of the crowd who turned out to see him at the airport.

"At that time, we had employment. We had jobs. There was peace. It was 100,000 times better than today," said Muhammed Iqbal from Karachi.

Musharraf is fondly remembered by many people in this city of 18 million people where he heavily backed the Muttahida Quami Movement ? the city's dominant political party.

But Musharraf's welcoming party, estimated at between 1,000 and 2,000, was small compared with the hundreds of thousands of people who thronged this same terminal when Benazir Bhutto returned to Pakistan or the tens of thousands who turned out Saturday night for a rally in Lahore for cricketer-turned-politician Imran Khan.

Supporters threw rose petals and enthusiastically waved flags emblazoned with pictures of Musharraf and Mohammed Ali Jinnah, the founding father of Pakistan, but their energy did not mask their numbers.

"If he claims nationwide support, that would be a joke," said Rasul Bakhsh Rais, from the Lahore University of Management Sciences. "I have never seen such a misplaced optimism about oneself."

Musharraf was whisked out of the airport inside an armored vehicle, surrounded by a phalanx of police and paramilitary security forces. It was a reminder of the security threats Musharraf faces.

The former general angered many militants with his decision in the wake of the Sept. 11, 2001 attacks to back the U.S. in its invasion of Afghanistan and cut off ties with the Taliban. Militants as well as many other Pakistanis saw him as carrying out the American agenda in Pakistan.

Militants were further infuriated with Musharraf when he decided in 2007 to raid a mosque in Islamabad that had become a center for militants opposed to the U.S. Pakistani officials said 102 people, mostly supporters of the mosque, died in the week-long operation.

The Pakistan Taliban vowed to kill him in a video released on Saturday. One of the featured speakers in the video ? former Pakistan Air Force officer Adnan Rashid ? was convicted of helping plot an assassination attempt against Musharraf back in 2003 when a suicide bomber tried to ram his vehicle. Rashid was imprisoned, but he escaped during a jail break orchestrated by the Taliban. In the video, he said Musharraf should surrender himself to the Taliban or prepare to be hit again.

"The mujahedeen of Islam have prepared a death squad to send Pervez Musharraf to hell," Rashid warned.

A serious security threat prompted the Pakistani police to cancel a rally that supporters had wanted to hold for Musharraf Sunday afternoon near Jinnah's mausoleum. And organizers at the airport repeatedly asked his boisterous supporters to move away from the front of the terminal so Musharraf could go outside to greet people.

The former president plans to spend a few days at a hotel in Karachi, where he and his team will hash out their plan for the upcoming election, said spokeswoman Saima Ali Dada. He will then travel to Islamabad. Meanwhile, his legal team will meet to decide the best way to respond to the charges against him.

Musharraf has been implicated in the 2007 assassination of Bhutto, as well as the killing of Akbar Bugti, a Baluch nationalist leader who died in August 2006 after a standoff with the Pakistani military. In another case, he's accused of illegally removing a number of judges, including the chief justice of the supreme court.

His return to Pakistan was made easier when a court in Sindh province where Karachi is located granted him preemptive bail, which essentially meant he could not be arrested immediately upon landing. But he must appear before a court within 10 days, and there is no guarantee that he won't be arrested in the future.

Human Rights Watch has called on the Pakistani government to prosecute him for abuses he is alleged to have committed during his time in office.

Regardless of his political future, Musharraf appeared happy to be back on Pakistani soil.

Soon after he landed, Musharraf tweeted: "Thrilled to be back home."

___

Associated Press writers Rasool Dawar in Peshawar, Pakistan, and Zarar Khan in Islamabad contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-03-24-Pakistan/id-27de19f33305425190200f9c457d861f

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